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Heme Oxygenase-1-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (1) Bacterial (1) Endogenous Metabolite (2) Influenza Virus (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (4) NO Synthase (1) Prostaglandin Receptor (1) Reactive Oxygen Species (8) Ribosomal S6 Kinase (RSK) (1) STAT (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111798

**Heme Oxygenase-1-IN-1** 5 Publications Verification	Reactive Oxygen Species	Cancer
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .

HY-111798A

Heme Oxygenase-1-IN-1 hydrochloride 5 Publications Verification	Reactive Oxygen Species	Cancer
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC₅₀ of 0.25 μM .

HY-B2184

Sofalcone	Autophagy Bacterial	Infection Inflammation/Immunology
Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1** (HO-1) in gastric epithelium.

HY-153020

HIF-PHD-IN-3	Reactive Oxygen Species	Cardiovascular Disease
HIF-PHD-IN-3 (compound 4) is a potent hiPSC-CM cardioprotective scaffold. HIF-PHD-IN-3 can induce upregulation of **heme oxygenase-1** .

HY-B2184S

Sofalcone-d4	Isotope-Labeled Compounds	Infection Inflammation/Immunology
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1** (HO-1) in gastric epithelium.

HY-101194

Tin protoporphyrin IX dichloride 15+ Cited Publications TIN-protoporphyrIN IX; Sn-ProtoporphyrIN; SnPPIX
Tin protoporphyrin IX dichloride (SnPPIX) is a potent **Heme oxygenase-1 (HO-1)** inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .

HY-134608

Cobalt protoporphyrin IX Co-PPIX	Reactive Oxygen Species Influenza Virus	Infection
Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .

HY-118487

OB-24	Others	Cancer
OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA) .

HY-N0643

Carnosol 5+ Cited Publications	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-124815

CP-312	Reactive Oxygen Species	Others
CP-312 is a potent **Heme Oxygenase-1 (HO-1)** inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress .

HY-N0061

Ethyl ferulate 1 Publications Verification	Reactive Oxygen Species	Neurological Disease
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-N0761A

trans-Isoferulic acid trans-3-Hydroxy-4-methoxycINnamic acid	NO Synthase Prostaglandin Receptor	Inflammation/Immunology
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-N2535

Coniferaldehyde 4-Hydroxy-3-methoxycINnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of **heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis** through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N6953

Garcinone D 2 Publications Verification	STAT Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), **heme oxygenase-1 (HO-1)** in concentration- and time- dependent manners .

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 28 Publications Verification Zn(II)-protoporphyrIN IX; ZnPP; ZINc ProtoporphyrIN-9	Reactive Oxygen Species Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive **heme oxygenase-1 (HO-1)** inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂ . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 0.575 µM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows not cytotoxic activity in ARPE19 cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0643

Carnosol 5+ Cited Publications	Structural Classification Classification of Application Fields Brachyclados megalanthus Speg. Food Preservation Research Source classification Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-N0061

Ethyl ferulate 1 Publications Verification	Structural Classification Monophenols Simple Phenylpropanols Source classification Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae	Reactive Oxygen Species
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-N0761A

trans-Isoferulic acid trans-3-Hydroxy-4-methoxycINnamic acid	Ketones, Aldehydes, Acids Source classification Ranunculaceae Plants	NO Synthase Prostaglandin Receptor
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-N2535

Coniferaldehyde 4-Hydroxy-3-methoxycINnamaldehyde	Structural Classification Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of **heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis** through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N6953

Garcinone D 2 Publications Verification	Xanthones Source classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants	STAT Keap1-Nrf2 Reactive Oxygen Species
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), **heme oxygenase-1 (HO-1)** in concentration- and time- dependent manners .

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 28 Publications Verification Zn(II)-protoporphyrIN IX; ZnPP; ZINc ProtoporphyrIN-9	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite Apoptosis
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive **heme oxygenase-1 (HO-1)** inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂ . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

Cat. No.	Product Name	Chemical Structure

HY-B2184S

Sofalcone-d4

Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

Sofalcone-d4
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1** (HO-1) in gastric epithelium.

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Heme Oxygenase-1-IN-1

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products